Lipitor, which was introduced by Pfizer back in 1997, is expected to be the drug with the third highest lifetime sales at the end of 2028. As of end-2022, the cholesterol-lowering drug aggregated lifetime sales of 172 billion U.S. dollars, which is expected to increase for some additional six billion dollars until 2028.
Projected leading 10 pharmaceutical products worldwide based on lifetime sales as of 2028
(in billion U.S. dollars)
Drug name (launch year)
Sales until end-2022
Sales 2023-2028 (forecast)
Humira (2003)
219
45
Keytruda (2015)
77
179
Lipitor (1997)
172
6
Enbrel (1998)
133
22
Comirnaty (2020)
77
76
Remicade (1998)
124
10
Rituxan (1997)
128
7
Opdivo (2014)
53
81
Eliquis (2011)
57
76
Eylea (2011)
66
54
Created with Highcharts 7.2.2Drug name (launch year)Lifetime sales from launch in billion U.S. dollars264264256256178178155155153153134134135135134134133133120120Sales until end-2022Sales 2023-2028 (forecast)Humira (2003)Keytruda (2015)Lipitor (1997)Enbrel (1998)Comirnaty (2020)Remicade (1998)Rituxan (1997)Opdivo (2014)Eliquis (2011)Eylea (2011)
020406080100120140160180200220240260280300
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Evaluate Vantage. (January 31, 2023). Projected leading 10 pharmaceutical products worldwide based on lifetime sales as of 2028 (in billion U.S. dollars) [Graph]. In Statista. Retrieved May 13, 2025, from https://www.statista.com/statistics/1089322/top-drugs-by-lifetime-sales-globally/
Evaluate Vantage. "Projected leading 10 pharmaceutical products worldwide based on lifetime sales as of 2028 (in billion U.S. dollars)." Chart. January 31, 2023. Statista. Accessed May 13, 2025. https://www.statista.com/statistics/1089322/top-drugs-by-lifetime-sales-globally/
Evaluate Vantage. (2023). Projected leading 10 pharmaceutical products worldwide based on lifetime sales as of 2028 (in billion U.S. dollars). Statista. Statista Inc.. Accessed: May 13, 2025. https://www.statista.com/statistics/1089322/top-drugs-by-lifetime-sales-globally/
Evaluate Vantage. "Projected Leading 10 Pharmaceutical Products Worldwide Based on Lifetime Sales as of 2028 (in Billion U.S. Dollars)." Statista, Statista Inc., 31 Jan 2023, https://www.statista.com/statistics/1089322/top-drugs-by-lifetime-sales-globally/
Evaluate Vantage, Projected leading 10 pharmaceutical products worldwide based on lifetime sales as of 2028 (in billion U.S. dollars) Statista, https://www.statista.com/statistics/1089322/top-drugs-by-lifetime-sales-globally/ (last visited May 13, 2025)
Projected leading 10 pharmaceutical products worldwide based on lifetime sales as of 2028 (in billion U.S. dollars) [Graph], Evaluate Vantage, January 31, 2023. [Online]. Available: https://www.statista.com/statistics/1089322/top-drugs-by-lifetime-sales-globally/
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