As of December 31, 2022, around 8,863 cases of pyrexia (fever) had been reported after receiving the Moderna vaccine against COVID-19 in Spain. Similarly to the adverse events recorded with the BioNTech-Pfizer vaccine, pyrexia was on top of the list, followed by headache and myalgia, which amounted to around 4,378 and 3,412 notified cases, respectively. As of that date, more than 24 million Spikevax doses (Moderna) had been administered in the country.
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Most common adverse events reported after receiving the Moderna (Spikevax) vaccine against COVID-19 in Spain as of December 31, 2022
Characteristic
Number of cases
Pyrexia
8,863
Headache
4,378
Myalgia
3,412
Discomfort
3,101
Pain in the vaccination area
2,903
Fatigue
1,508
Chills
1,443
Sickness
1,378
Lymphadenopathy
1,141
Arthralgia
1,013
Created with Highcharts 7.2.2Number of cases8,8638,8634,3784,3783,4123,4123,1013,1012,9032,9031,5081,5081,4431,4431,3781,3781,1411,1411,0131,013PyrexiaHeadacheMyalgiaDiscomfortPain in the vaccination areaFatigueChillsSicknessLymphadenopathyArthralgia
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Includes any kind of adverse event notified after receiving the coronavirus (COVID-19) vaccine. Adverse events are not to be interpreted as induced by the vaccine until a casual relationship is confirmed.
As of December 31, 2022, a total of 24,139,935 doses of the Moderna vaccine (Spikevax original) had been administered in Spain.
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AEMPS. (January 19, 2023). Most common adverse events reported after receiving the Moderna (Spikevax) vaccine against COVID-19 in Spain as of December 31, 2022 [Graph]. In Statista. Retrieved June 30, 2025, from https://www.statista.com/statistics/1220406/moderna-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS. "Most common adverse events reported after receiving the Moderna (Spikevax) vaccine against COVID-19 in Spain as of December 31, 2022." Chart. January 19, 2023. Statista. Accessed June 30, 2025. https://www.statista.com/statistics/1220406/moderna-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS. (2023). Most common adverse events reported after receiving the Moderna (Spikevax) vaccine against COVID-19 in Spain as of December 31, 2022. Statista. Statista Inc.. Accessed: June 30, 2025. https://www.statista.com/statistics/1220406/moderna-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS. "Most Common Adverse Events Reported after Receiving The Moderna (Spikevax) Vaccine against Covid-19 in Spain as of December 31, 2022." Statista, Statista Inc., 19 Jan 2023, https://www.statista.com/statistics/1220406/moderna-vaccine-most-common-adverse-events-reported-in-spain/
AEMPS, Most common adverse events reported after receiving the Moderna (Spikevax) vaccine against COVID-19 in Spain as of December 31, 2022 Statista, https://www.statista.com/statistics/1220406/moderna-vaccine-most-common-adverse-events-reported-in-spain/ (last visited June 30, 2025)
Most common adverse events reported after receiving the Moderna (Spikevax) vaccine against COVID-19 in Spain as of December 31, 2022 [Graph], AEMPS, January 19, 2023. [Online]. Available: https://www.statista.com/statistics/1220406/moderna-vaccine-most-common-adverse-events-reported-in-spain/
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