Between 2018 and 2023, American companies introduced a total of *** new chemical or biological substances. Within the same period, Europe and Japan produced ** and ** new entities, respectively.
Total R&D spending
In 2023, the global pharmaceutical industry spent an estimated *** billion U.S. dollars on research and development. Global pharmaceutical R&D expenditures have been increasing with (almost) each consecutive year since 2012 and are expected to keep growing: worldwide R&D spending is projected to reach over *** billion U.S. dollars by 2028.
Patent expiration
Once the patent protection date of a branded drug expires, other pharmaceutical companies can take this opportunity to make cheaper versions of the original (a.k.a. generics). In 2023, about ** billion U.S. dollars’ worth of prescription drug revenue was at risk due to patent expiration worldwide.
EFPIA stands for the European Federation of Pharmaceutical Industries and Associations.
This statistic was assembled from several editions of this report.
* First period for which a separated value for China was provided.
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EFPIA. (June 24, 2024). Number of new chemical or biological entities developed between 1998 and 2023, by region of origin [Graph]. In Statista. Retrieved June 27, 2025, from https://www.statista.com/statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA. "Number of new chemical or biological entities developed between 1998 and 2023, by region of origin." Chart. June 24, 2024. Statista. Accessed June 27, 2025. https://www.statista.com/statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA. (2024). Number of new chemical or biological entities developed between 1998 and 2023, by region of origin. Statista. Statista Inc.. Accessed: June 27, 2025. https://www.statista.com/statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA. "Number of New Chemical or Biological Entities Developed between 1998 and 2023, by Region of Origin." Statista, Statista Inc., 24 Jun 2024, https://www.statista.com/statistics/275262/pharmaceutical-industry-new-entities-by-region/
EFPIA, Number of new chemical or biological entities developed between 1998 and 2023, by region of origin Statista, https://www.statista.com/statistics/275262/pharmaceutical-industry-new-entities-by-region/ (last visited June 27, 2025)
Number of new chemical or biological entities developed between 1998 and 2023, by region of origin [Graph], EFPIA, June 24, 2024. [Online]. Available: https://www.statista.com/statistics/275262/pharmaceutical-industry-new-entities-by-region/
